Surface Modification of Optimized Asenapine Maleate Loaded Solid Lipid Nanoparticles Using Box-Behnken Design

Aim: The aim of the present study was to design and evaluate solid lipid nanoparticles Asenapine maleate (<2% bioavailability) enhance its oral bioavailability surface modification for brain targeting.
 Methods: A modified solvent injection method used produce loaded nanoparticles. RSM 3-factor, 3-level Box-Behnken applied effect three independent variables, concentrations (A), drug (B) surfactant (C) on dependent particles size (Y1), entrapment efficiency (Y2), release (Y3). 3-D response plots were drawn optimized formulation selected based desirability factor. Then it coated with tween 80 ease permeability through blood barrier due intact absorption nanoparticles.
 Results: results showed average particle 108.9 nm, 78.62%, in vitro 98.88±0.102% at 36 hr pH 7.4. Morphologically, almost spherical shape uniform distribution. Targeting after administration confirmed by fluorescence microscopy studies male albino wistar strain rats. This research also envisaged that there is a >85% cell viability up 125µg/ ml concentration MTT assay.
 Conclusion: Thus, current successfully designed, developed an SLN using targeting treat Schizophrenia bypassing first pass metabolism enhanced bioavailability.